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The Psilocybin-Blunting Effects of SSRIs and Antidepressants

Serotonergic medications like SSRIs have been on the market for treatment of mental health conditions like depression and anxiety for several decades now, and they’ve maintained a steady public backing since their conception. 

More recently though, the cultural discussion surrounding these regimens has addressed a wide-reaching dissatisfaction with their often intolerable side effects. 

It’s this longing for more deep-rooted and durable antidepressant and integrative mental health treatments that have given our psychedelic renaissance such impassioned communal reinforcement. 

To the best of our knowledge, this may be the most comprehensive analysis and review to date on the chemico-biological interactions of these medicines in each of their respective drug classes. 

We explore the mechanisms by which antidepressants can reduce or amplify the potency of a psychedelic trip and the safety-first steps you can take to reduce negative interactions.

Whether you’re looking to replace a current medication with psilocybin therapy or seeking to combine traditional talk therapy with psychedelic therapy, this discussion on the psychedelic drug interactions will undoubtedly inform your next steps.

Key Takeaways

  • Tapering off antidepressants prior to a psychedelic experience mitigates the blunting effects, allowing for the psychedelic medicine to work uninhibited. 
  • When tapering off of a prescribed medication, doing so 2 weeks in advance and under the care of a facilitator provides a supportive and safe container for this delicate process.
  • Microdosing may be an effective alternative to prescription antidepressants. 
  • Psychedelic Passage: Your Psychedelic Concierge — The easy, legal way to find trustworthy psilocybin guides, facilitators and psychedelic assisted therapy near you in the United States.

Download Our Free Psilocybin Sourcing Guide

For harm-reduction purposes, we provide links to online psilocybin vendors, local stores, delivery services, and spore vendors for growing your own medicine at home.

Antidepressants That Interact With Psychedelic Medicine

Selective serotonin reuptake inhibitors (SSRIs)

  • Citalopram (Celexa)
  • Escitalopram (Lexapro)
  • Fluoxetine (Prozac)
  • Fluvoxamine (Luvox)
  • Fluvoxamine CR (Luvox CR)
  • Paroxetine (Paxil)
  • Paroxetine CR (Paxil CR)
  • Sertraline (Zoloft)

Serotonin-norepinephrine reuptake inhibitors (SNRIs)

  • Desvenlafaxine (Pristiq)
  • Duloxetine (Cymbalta)
  • Venlafaxine (Effexor)
  • Venlafaxine XR (Effexor XR)
  • Milnacipran (Savella)
  • Levomilnacipran (Fetzima)

Serotonin partial agonist/reuptake inhibitor (SPARIs)

  • Vilazodone (Viibryd)
  • Vortioxetine (Trintellix)

Tricyclic antidepressants (TCAs)

  • Amitriptyline (Elavil)
  • Desipramine (Norpramin)
  • Doxepin (Sinequan)
  • Imipramine (Tofranil)
  • Nortriptyline (Pamelor)
  • Amoxapine
  • Clomipramine (Anafranil)
  • Maprotiline (Ludiomil)
  • Trimipramine (Surmontil)
  • Protriptyline (Vivactil)

Monoamine oxidase inhibitors (MAOIs)

  • Phenelzine (Nardil)
  • Selegiline (Emsam)
  • Tranylcypromine (Marplan)
  • Isocarboxazid (Parnate)
  • Moclobemide

Norepinephrine-dopamine reuptake inhibitors (NDRIs)

  • Bupropion (Wellbutrin, Aplenzin)

Atypical agents

  • Mirtazapine (Remeron)
  • Nefazodone (Serzone)
  • Trazodone (Desyrel, Oleptro)
  • Buspirone (Buspar)

Expectation Management for the Psychedelic Trip 

Assuming well informed expectations for psilocybin therapy is key for having an experience that’s tailored to your body’s metabolic needs and to your present mental health conditions. 

While some studies on the matter have yielded contradicting findings, a substantial number of anecdotal reports draw a significant, negative correlation between prolonged use of serotonergic medications and the degree to which a psychedelic trip can be inwardly experienced.

“I am on 200mg of Sertraline and took 3.5gs of shrooms last night. It basically felt the same as the first time I smoked pot. Got the munchies, but no hallucinations unless I closed my eyes, and even then there was hardly anything.” –Reddit User 

“I take Zoloft and can NOT trip on shrooms. I’ve tried a few times. I think the Zoloft blocks the trip” –Reddit User

In other words, people who are prescribed these pharmaceutical drugs and take them routinely, have reported experiencing little to no hallucinogenic effects on a standard dose of tryptamines, like psilocybin mushrooms and LSD.

Though this phenomena seems to expand its presence into a plethora of other psychedelic drugs, like Phenethylamines (MDMA, mescaline), today we’ll be settling our attention on the trip-suppressing effects of antidepressant pharmaceuticals.

Let’s begin by discussing the mechanisms that scientists believe are encouraging this mind-body discord. 

Please note that the infancy of the psychedelic medicine industry unfortunately limits the range of controlled research studies and clinical trials that have investigated less-discussed, sometimes case-specific nuances of our highly variant body of psychedelics.

Though that’s caused most of our current research to rely largely on anecdotal reports, it’s important to recognize the high and widespread frequency of these discouraging interactions. 

For the purpose of offering a comprehensive analysis, we’ll be piecing together the findings of several observational studies, to paint a more conclusive scientific explanation for this absorption-related dysfunction.

Current Research Studies on Antidepressants and Psychedelics

In a 1999 study, researchers deduced that the perceptual distortions experienced from hallucinogenic drugs are mainly hosted by 5-HT2A (serotonin) receptors through glutamatergic transmissions occurring in the cerebral cortex (Aghajanian & Malek). 

Substances like LSD and psilocybin are bicyclicly structured into an indole-shaped ring. This form allows them to perfectly attach themselves to our brain’s 5-HT2A (serotonin) receptors. 

Picture this as the communion of a particular key with its corresponding lock, like the perfect piece to a complex puzzle. 

Now that we understand a small part of psilocybin’s cerebral route, let’s take a look at the mechanisms of antidepressants.

A 2004 study led by Pau Celada and colleagues in 2004, investigated the biological mechanisms of antidepressants. Their findings concluded that antidepressants act as antagonists at the 5-HT2A receptors. (Amargos-Bosch et al.).

What does this mean? Well, first and foremost, it tells us that compounds like LSD and psilocybin target the same receptors as antidepressants

It also suggests a conflict of chemical interest, where two drugs are attempting to act on serotonin receptors to alter brain function. 

While psilocybin is trying to bind to and activate 5-HT2A receptors (in order to elicit hallucinogenic effects), antidepressants are attaching themselves to these same receptors, then blocking the sites to prevent further 5-HTR binding

This obstructs our body’s biological response to psychedelic drugs that act on 5-HT2AR, since their serotonin chemicals cannot be freely absorbed by the clogged receptor. 

Essentially, antidepressants increase extracellular serotonin levels in order to inhibit nerve cells from reabsorbing serotonin that was previously produced by it. 

By hindering reabsorption, our brains are given a larger supply of unoccupied serotonin to amplify transmission between its neurons.

A large number of studies hypothesize that down-regulation is the culprit of our brain’s inability to metabolize serotonin, after prolonged antidepressant use. One 2013 study produced findings that supported this notion (Gray et al.).

The study recruited 19 unmedicated subjects with major depressive disorder and compared the binding function of their 5-HT receptors before and after a 5-9 week period of self medication with SSRIs. 

Results showed an 18% downregulation of binding functions to 5-HT autoreceptors, congruous with previously conducted animal studies. 

Do SSRIs Make Psychedelics Stop Working?

This initial reduction is thought to increase the firing rate of serotonergic neurons in later stages of treatment, magnifying this communication by releasing more serotonin. 

However, post-treatment results indicate that this surge is not durably maintained without the antidepressant, and instead it causes our brains to have more trouble producing serotonin than it did pre-treatment.

So the big question–how does these findings communicate the brain’s inability to experience normal levels of psychedelic hallucinations, during and after antidepressant use? 

Very simply, while on an antidepressant and in the weeks to months after discontinuation, our brains don’t allow psilocybin’s main chemical (serotonin) to attach itself to our serotonin receptors.

Since 5HT receptors are thought to be the main cause of psychedelic effects, an inability to permeate the serotonin reuptake pump means an inability to feel this fungus’ psychoactive properties. 

Also, someone who’s only recently stopped prolonged use of antidepressants, may not feel a standard psychedelic dose as potently as someone who’s never been on a serotonergic medication.

Of the very few observational studies directly investigating this phenomenon, a 1996 study recruited 32 volunteers to report on the intensity of their psychedelic experiences while on heavy use of antidepressants (fluoxetine, paroxetine, sertraline, trazodone) (Bronson et al.).

88% experienced a significant reduction of LSD effects after more than 3 weeks of antidepressant dosing.

A 2017 study agreed with these findings, coming to the conclusion that antidepressants evoke 5HT2AR downregulation, consequently blunting the effects of psychedelic drugs (Carhart-Harris & Nutt).

One of their earlier studies examined the effects of tricyclic antidepressants on the LSD experience. After seeking out 10 subjects who had been on TCAs or MAOIs for at least 3 weeks, they gathered their reports on the LSD experience. 

A standardized questionnaire revealed a significant correlation between chronic use of TCAs and amplified hallucinatory distortions on LSD. Conversely, participants on MAOIs experienced a significant reduction of subjective LSD effects. 

However, another 2017 study came to a much different conclusion. This study found that MAOIs increased the accumulation of 5-MeO-DMT in the central nervous system and enhanced its interaction with 5-HT2A receptors (Halberstadt).

This suggests that MAOIs may increase the effects of 5-MeO-DMT and other tryptamine hallucinogens, rather than decreasing their effects.

We should note though, the study primarily focused on the alteration of the pharmacodynamics of 5-MeO-DMT by MAOIs and did not directly investigate the subjective effects of the combination of MAOIs and tryptamine hallucinogens in humans.

A 2016 literary review by PK Gillman also concluded that MAOIs should not be taken with drugs intended to release serotonin as their interaction could potentially cause serotonin syndrome—a bodily reaction caused by an excessive amount of amassed serotonin, which could be fatal. 

He also agreed that this combination could reduce the effects of psychedelics like MDMA and ecstasy.

Anecdotally, we’re seeing that chronic use of irreversible and non-selective MAOIs can diminish responses to serotonegric psychedelics. Acute use of reversible MAOIS (e.g. harmala alkaloids) can potentiate responses.

To be clear, combining psychedelics with any drug that inhibits serotonin reuptake will increase the chances of serotonin syndrome, also known as serotonin toxicity. 

If serotonin is not able to be metabolized, it can overaccumulation in the brain, leading to potentially fatal outcomes.

Buspirone’s blunting effects on psychedelics are not caused by inhibition of reuptake, but by their partial agonist properties that may compete with the psychedelic attempts to enter those same serotonin receptors. 

A 2016 study by Pokorny and colleagues used a double blind, within-subject design to analyze the effects of Buspirone on psilocybin hallucinations. 

The placebo group was given a small dose of ergotamine, an anti-migraine medication, to compare interactions against larger, regular doses of Buspirone. 

The Altered State of Consciousness rating scale was used to detail the subjects’ experiences which produced very strong evidence (p<0.001) for a significant decrease in visual hallucinations and a significant decrease in derealisation and depersonalisation (p=0.062), compared to main scale scores. 

Ergotamine did not produce any suppressing effects. These results conclude that Buspirone inhibits hallucinatory effects of psychedelic drugs.  

To those who’ve found themselves in this colorless situation, unable to experience the therapeutic effects of psychedelic medicine for many different conditions–never fear. 

There are steps we can take to ensure our bodies metabolize psilocybin as they can.

Restoring The Serotonin System After Antidepressant Use 

A 2019 study by Kathryn G. Commons and colleagues suggests that autoreceptor desensitization isn’t an effect of antidepressants. 

They argue against the hypothesis that long term use of antidepressant medications overstimulates serotonin receptors and permanently reduces their ability to continue emitting this autoinhibitory feedback. 

Their research suggests that although desensitization may occur, the unaffected receptors do continue inhibiting reuptake, returning our brain to baseline levels of serotonin production using the compensatory feedback inhibitors that remain. 

These findings illustrate a positive outcome that seems in line with many of our client’s experiences: After tapering off antidepressants, the brain’s serotonin system returns close-enough to baseline for journeyers to feel the effects of psychedelic medicine.

What Have We Seen Anecdotally With Our Clients?

As a company who facilitates psychedelic journeys professionally, we’ve worked with both clients who are on antidepressants and those who are not. 

Our take is that antidepressants don’t pose a safety concern when combined with psilocybin treatment, but they do tend to interfere with client expectations.

Chances are if you’re exploring an intentional psychedelic experience, you’re seeking some sort of change. 

The challenge is this—what happens if you put all the time, energy, and money towards preparing for a psychedelic experience only to have nothing happen? 

For most people, the answer is disappointment. This is why we typically discourage combining serotonergic medications with psilocybin.

The interesting thing is that we’ve had clients send us this study from 2021 which shows the SSRI’s don’t interfere with the psychedelic experience—but we’ve found that doesn’t hold true–at least not with all medications.

While the study is a great data point, it’s also important to consider the results we’ve seen anecdotally working with clients first-hand over the last several years.

We’ve sat with some clients who are taking SSRIs and are able to have psychedelic experiences—they typically just need a higher dose of psilocybin. 

Alternatively, we’ve sat with clients who are taking SSRIs who eat 10+ grams of mushrooms and experience no effects at all.

So, it’s not that this study is ‘wrong’—just that it doesn’t paint the full picture. 

At this point in time, we don’t have enough information to accurately predict whether a client will have a significant psychedelic experience while taking SSRIs—some will and some won’t. 

The question is, is that a risk you’re willing to take as a journeyer? Only you know the answer to that question.

How Long Do I Need to Discontinue Use?

Understanding what should be naturally expected from our body’s present conditions is step number one. Conscious and safe preparation for the psychedelic experience in step number two for ensuring you preserve your physical and mental health. 

Before diving into some relevant and effective options for getting the most out of your magic mushrooms, please be advised that cessation of any medical treatment like antidepressants, should always be discussed with your psychiatrist beforehand. 

Antidepressant dosage reduction or termination should always be done under the supervised care and direction of a medical professional and should never be abruptly withdrawn. 

Abrupt discontinuation of antidepressant medications can worsen mental health conditions and cause emotional instability and volatility.

Having said that, we understand it can be intimidating to approach your doctor with psychedelic-related concerns. If you need some guidance, check out our article on how to speak with your doctor about psilocybin therapy. 

Now, let’s review what can be done to promote better absorption of psilocybin to hopefully yield more adequately-weighted therapeutic psychedelic effects:

  • If you’re taking any of the SSRIs or SNRIs referenced in the first chart, including SPARI drugs like Vibryyd (Vilazodone) or Trintellix (Vortioxetine), with the exception of fluoxetine, consider tapering off of your meds no less than 2 weeks before your psychedelic journey. 

If you’re on fluoxetine, discontinuation of medication should occur at least 6 weeks prior to your journey. By the time you’re ready to embark on the trip, you should have ceased consumption of any SSRI drug.

  • Fortunately, there are no reports of reduced psychedelic effects on Wellbutrin, but some would advise tapering medication as a precaution, correlating the length of premeditated discontinuation to the potency of desired effects.
  • On a Mirtazapine medication, tapering should also allow for a 2 week period of discontinued use, prior to your trip. Mirtazapine could dull psychedelic experiences, similar to SSRIs and SNRIs, but its blunting mechanisms lie in a blockage of the 5HT2A receptor, rather than blocking the 5HT reuptake pump.
  • This same 2 week tapering regimen should be applied for those on Tricyclic antidepressants. Discontinuation before a psychedelic trip is advised due to the potential for experiencing intensified psychedelic effects and serotonin syndrome.
  • If on Trazodone, tapering and discontinuation should be in effect a minimum of 5 days before a trip to prevent blunting effects.
  •  
  • Buspirone consumers should also follow the 5-day minimum to avoid the same events.
  • MAOIs should be discontinued through tapering 2 weeks before a trip for these same reasons.
  • The combination of Lithium and psilocybin appears to pose potential risks, as it may lead to toxicity and increase the likelihood of adverse outcomes such as seizures, serotonin toxicity, or negative experiences.

How Microdosing & Psychotropic Medication Can Help

Microdosing psilocybin mushrooms can potentially be helpful for those looking to taper off of psychotropic medications such as antidepressants, anti-anxiety medications, stimulants, antipsychotics, and mood stabilizers. 

This is because psilocybin binds to the 5-HT receptors which are linked to mood, social behavior, sexual desire, memory, sleep, appetite and digestion among many other things. 

In other words, the benefit to including microdoses of psilocybin while tapering off of pharmaceuticals is that it provides a natural supplement to the systems influenced by psychotropic medications.

This effect lessens or even eliminates the pharmaceutical withdrawal side effects altogether (things like brain zaps, fatigue, irritability, etc.). 

Many people report feeling lighter and more alive while taking microdoses with their psychotropic medications, even while tapering.

The other benefit to microdosing during the tapering process is that it increases neuroplasticity in the brain (Ly et al., 2018). Although microdosing effects are sub-perceptual, they allow for the brain to form and reorganize synaptic connections. 

In other words, a microdosing protocol allows the brain to be re-wired in a way such that it is not dependent on pharmaceutical medications. 

In summary, microdosing psilocybin potentially allows one to taper off of their psychotropic medications faster and with far fewer withdrawal side effects.

Important Note: Because many psychotropic medications also work through the serotonin pathways, it will likely require a higher dose of psilocybin for the effects to be felt. This is normal, simply adjust your dosage as necessary.

How to Determine Your Psychedelic Dose

Until recently, assessing the potency of psychedelic substances required sending samples to a lab, a costly and time-consuming process. However, recent advancements have led to the availability of at-home testing kits, including ones for mushroom material.

These at-home kits, like QTests by Miraculix, not only confirm substance presence but also provide precise measurements of potency, either in milligrams or as a percentage. This enables users to accurately dose and tailor their experiences, crucial for avoiding overwhelming or underwhelming effects.

Understanding potency is essential for therapeutic use, as different doses can result in vastly different experiences. For microdosing, it ensures consistent daily doses. 

Qtests offers:

Test kit for Potency of Psychedelics at Home

QTests provide a scientifically validated method for determining the concentration of unregulated substances, granting both journeyers greater control over treatment processes and safeguarding the potential benefits of psychedelic therapies. 

Explore Harm Reduction Products:

Helpful Tips For Tapering Off of Antidepressants

The best way to taper off, adjust, or eliminate any medication is with the supervision and guidance of your prescribing doctor or psychiatrist

However, we also recognize that many doctors are better at prescribing medications than they are at helping people taper. 

This often results in them recommending tapering regimens that are far too aggressive and lead to significant withdrawal symptoms.

For most people, these withdrawal symptoms are so disruptive and debilitating that it seems easier to continue to use a particular pharmaceutical drug in order to avoid the return of depressive symptoms. 

In an effort to provide you with some general guidelines, we’ve outlined a tapering protocol established by Adele Framer, the founder of survivingantidepressants.org:

Since 2011, Surviving Antidepressants has advocated a conservative 10% reduction per month of the most recent dose – an exponential taper, the size of each reduction becoming progressively smaller, approximating the hyperbolic method endorsed by recent research (Framer, 2021). 

These gradual tapers to minimize withdrawal symptoms typically require the creation of customized dosages and take many months to several years, depending on individual tolerance for dosage reduction.

Why reductions at monthly intervals? Although diagnostic criteria require withdrawal to appear within a week of dosage reduction, our members report it can take several weeks (or more) for them to appear. 

People may not recognize incipient symptoms themselves or it may take some time for symptoms to culminate. Pharmacokinetically, enough residual drug may be active to forestall withdrawal symptoms through the washout period.

If the taper proceeds without significant problems, for most drugs, people generally reduce to less than 2.5% of the original dosage before stopping completely. 

Given the potential lag time in emergence of withdrawal side effects, the person should be monitored for at least 3 months after discontinuation, with low-dose reinstatement at the ready should subsequent withdrawal symptoms appear.

To reiterate, taper slowly and listen to your body at all times. It is common for withdrawal side effects to have a delayed onset up to 2 weeks. 

Oftentimes a more conservative tapering process will be faster in the long run than forcing things and ending up in the start/stop cycle.

What About Medications Other Than Antidepressants?

Stimulant medications like Adderall and Vyvanse have a much shorter half life. Prescription stimulants may not affect the psychedelic experience noticeably. For more information, check out “Can You Mix Psychedelic Mushrooms With Adderall and Stimulants?“.

The procedure for using psychedelics if you’re on opioids may be dependent on the specific medication you’re on. However, a medication like Wellbutrin (Bupropion) is a non-issue in combination with serotonergic psychedelics. 

Bupropion primarily affects the norepinephrine and dopamine systems, with minimal direct impact on serotonin. Psilocin, on the other hand, primarily affects serotonin receptors. This suggests that the two drugs have different primary mechanisms of action and do not directly interact at the receptor level.

Additionally, Bupropion is metabolized in the liver, primarily by CYP2B6, to its active metabolites. Psilocin is metabolized from psilocybin through a different pathway. Therefore, there is no known direct interaction between these metabolic pathways.

Atypical antipsychotics (e.g. chlorpromazine, risperidone, ketanserin) appear non-toxic but diminish responses to serotonergic psychedelics.

Typical antipsychotics (e.g. haloperidol) appear to increase risks of anxious ego-dissolution and dysphoric experience.

Buspirone appears non-toxic but may compete with psilocin or downregulate serotonin receptors to diminish responses.

When it comes to other psychotropic medications, we suggest speaking with our team of psychedelic concierges to ensure that all potential contraindications are accounted for. 

Drugs like benzodiazepines should never be tapered off of without consulting a medical professional. The withdrawal symptoms of benzodiazepines can be life threatening and should not be taken lightly.

Helpful Resources

Our Services & How We Support Your Psychedelic Journey

Psychedelic Passage is dedicated to supporting your psychedelic journey through providing access to safety resources and psychedelic facilitation services. 

We believe in the transformative potential of psychedelics when approached with the right knowledge, guidance, and preparation. Our commitment is centered on providing access to accurate and comprehensive information about these medicines.

We offer you access to a network of pre-vetted professional psychedelic facilitators who are experienced and well-trained, specializing in guiding individuals through their psychedelic experiences in a safe and supportive manner. 

They play a crucial role in ensuring a positive and enriching journey by providing guidance on contraindications, proper dosing, and general preparation.

On the day of your psychedelic journey, our facilitators are there to offer continuous support, creating a nurturing and comfortable environment for your experience. 

Overall, our organization strives to empower and support individuals on their psychedelic journey, offering a holistic approach that includes education, guidance, preparation, day-of support, and integration assistance.

Get Matched with a Trusted Psychedelic Therapy Provider Near You

Hi there! We sincerely hope that you’ve found valuable takeaways that resonate with your current intentions. To explore research-based education, stay updated with psychedelic news, and benefit from practical how-to articles, we encourage you to head over to our resources page.

If you’re seeking personalized advice and are prepared to take the first step toward a therapeutic psychedelic experience, we invite you to book a consultation with our team of experienced psychedelic concierges.

This consultation is more than just a conversation; it’s an opportunity to be matched with a trustworthy local facilitator. You’ll be seamlessly connected to our rigorously vetted network of psychedelic guides, ensuring potential matches align with your needs.

Psychedelic Passage offers confidence and peace of mind by alleviating the burden of having to guess who’s right for you. If you want to discover how Psychedelic Passage can help you, we empower you to learn more about our services and check out client testimonials from those who’ve gone before you.

Your healing path is uniquely yours, and our commitment is to serve you at every juncture. Psychedelic Passage: Your Psychedelic Concierge — The easy, legal way to find trustworthy psilocybin guides, facilitators and psychedelic assisted therapy near you in the United States.

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Frequently Asked Questions: Antidepressants & Psychedelics 

Q: Can I take antidepressants and psychedelics together?

It’s generally advised to avoid combining antidepressants with psychedelics due to potential interactions. Antidepressants, especially SSRIs, can diminish or alter the effects of psychedelics, making the experience unpredictable and potentially less effective.

Aside from psychedelics being blunted by antidepressants, combining the two could potentially increase the risk for serotonin syndrome, so it’s best to taper off prior to ingesting psychedelics.

Q: Can psychedelics be used as an alternative to traditional antidepressant medications?

Psychedelicsspecifically psilocybin—have been shown in recent studies to be an effective antidepressant and even treatment method for treatment-resistant depression.

However, they are not currently approved as a standard alternative to traditional antidepressants given the complex legality around these substances.

Q: How might psychedelics affect my mental health if I have a history of depression?

Because depression is a complex condition, there is no guarantee that taking a psychedelic will have a reliable effect (but then again, even prescribed medications have the same issue).

Overall, many studies suggest potential therapeutic benefits for depression, but in cases of extreme mental health issues, consulting a professional and having a great deal of support is pertinent if experimenting with these medicines.

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At Psychedelic Passage, we offer professional 1-on-1 guidance and companionship on your journey of healing. We simply can't sit back and let Americans continue to sit in silent suffering trying to battle mental health issues within a broken health care system, all while knowing that effective alternatives exist. We stand for the sacred, at-home, ceremonial use of psychedelics for consciousness exploration, which we believe to be a fundamental human right.

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