Click to download our Free Psilocybin Sourcing Guide

Download our Free Psilocybin Sourcing Guide

Register for Free Daily Introductory Q&A at 4:00 PST

Register for Free Daily Intro Q&A at 4:00 PST

Psilocybin Mushrooms and Bupropion (Wellbutrin) Drug Interaction

Learn about the potential interaction between psilocybin mushrooms and bupropion (Wellbutrin) in this comprehensive article. Understand how these substances work in the brain and what factors to consider for safe psychedelic experiences amidst concerns of drug interaction.

    As the landscape of mental health treatment continues to evolve, the resurgence of interest in psychedelic therapy offers many a glimmer of hope and curiosity.

    Psilocybin has sparked the fascination of researchers, clinicians, and those on a quest for healing. Amidst this exciting resurgence, many questions arise about the therapeutic potential of psychedelics within the context of modern medicine.

    As we set forth on this journey, understanding how psilocybin interacts with bupropion, or better known as Wellbutrin, becomes essential. Bupropion, prescribed for a range of mental health conditions including depression, adds another layer to the conversation about psychedelic exploration.

    As individuals consider embarking on journeys of healing and self-discovery with psychedelics, it’s only natural that questions bubble up about potential interactions between psilocybin and bupropion. Today, we’ll dive into these inquiries head-on.

    We’ll explore the inner workings of psilocybin and bupropion in the brain, uncovering how they dance together when taken in tandem. Plus, we’ll peek into the interactions of other antidepressants with psilocybin, offering a comprehensive view of how different medications might influence psychedelic experiences.

    Through this journey, our aim is to provide the knowledge and insights needed to navigate the intriguing crossroads of ancient wisdom and current medical treatments. Together, let’s embark on this adventure where the realms of consciousness and pharmacology meet, paving the way for new avenues toward holistic healing and mental well-being.

    Download Our Free Psilocybin Sourcing Guide

    For harm-reduction purposes, we provide links to online psilocybin vendors, local stores, delivery services, and spore vendors for growing your own medicine at home.

    Key Takeaways

        • Revival of Psychedelic Exploration: Among a resurgence of interest, psychedelic therapy blends ancient wisdom with modern research, unlocking its potential in mental health treatment and offering hope for transformative healing journeys.

        • Unlocking Bupropion Insights: Learning about bupropion’s mechanism of action and its little impact on psychedelic experiences helps individuals make informed decisions about combining medication with psychedelic therapy. 

        • Navigating Antidepressant Interactions: Understanding how antidepressants interact with psilocybin is crucial for safe and meaningful psychedelic experiences, guiding individuals towards informed choices in their therapeutic journeys.

        • Psychedelic Passage: Your Psychedelic Concierge — The easy, legal way to find trustworthy psilocybin guides, facilitators and psychedelic-assisted therapy near you in the United States.

      The Journey of Psychedelics in Mental Health

      Throughout history, psychedelics have played a significant role in various cultures for their profound effects on consciousness and spirituality. However, it wasn’t until the mid-20th century that psychedelics began to capture the attention of Western medicine and psychology.

      In the 1950s and 1960s, researchers explored the therapeutic potential of psychedelics, particularly in the treatment of psychiatric disorders like addiction, depression, and anxiety.

      Unfortunately, the widespread recreational use of psychedelics, combined with societal and political concerns, led to a crackdown on research, halting progress in the field.

      Fast forward to the 21st century, and we’re experiencing a resurgence of interest in psychedelic therapy. Advances in neuroscience, coupled with evolving attitudes towards mental health, have reignited scientific curiosity in these substances. Among them, psilocybin has emerged as a frontrunner in this renaissance.

      Why Psilocybin Mushrooms for Mental Health Treatment?

      Out of the many types of psychedelics out there, why is psilocybin one of the most used substances in psychedelic therapy?

      Psilocybin, a naturally occurring psychedelic compound found in approximately 200 different fungi species worldwide, has emerged as a leading contender in psychedelic therapy. Today, it stands as one of the most widely studied psychedelics in human research, thanks to several key advantages.

      In fact, according to the 2017 Global Drug Survey, psychedelic mushrooms rank as the safest drug, especially when it comes to needing emergency medical treatment.

      Recommended Reading: Can You Overdose on Mushrooms? U.S. Statistics on Psilocybin Deaths

      When considering why psilocybin is a favored option in psychedelic therapy, its comparatively shorter duration of effects stands out, rendering it an appealing choice for therapeutic exploration. Upon ingestion, its effects typically emerge within 30-60 minutes, reaching a peak around 90 minutes and lasting up to 6 hours.

      However, individual experiences may vary based on factors such as dosage, consumption method, tolerance levels, and physiological differences.

      Another compelling factor driving the use of psilocybin in therapeutic settings is its profound effects on consciousness and perception. Users often report experiences characterized by enhanced introspection, ego dissolution, and spiritual insights, making it conducive to therapeutic work.

      Recommended Reading: The Side Effects of Psilocybin or ‘Magic’ Mushroom Therapy

      Because of this, psilocybin has been shown to be effective in treating an array of mental health conditions, such as:

        Psilocybin has garnered recognition from regulatory bodies for its therapeutic potential. In 2018, the US Food and Drug Administration granted breakthrough therapy status to psilocybin for treatment-resistant depression, followed by a similar designation for major depressive disorder in 2019.

        Moreover, at a state level, Oregon passed Measure 109, paving the way for the manufacture, delivery, and administration of psilocybin in therapeutic contexts.

        Beyond its modern medical applications, psilocybin has a rich history of use in indigenous cultures for spiritual and healing purposes, particularly in South and Central America. This cultural and historical precedent lends further credence to its therapeutic use, providing a foundation for contemporary research and exploration.

        Recommended Reading: The Best Mushroom Strain For Psilocybin-Assisted Therapy

        The Future of Psychedelic Therapy: What Lies Ahead

        Looking ahead, the future of psychedelic therapy shines brightly in the healthcare field.

        Psychedelic therapy extends its reach beyond mental health, embracing a spectrum of physical ailments. Early studies hint at the potential benefits of psychedelics like psilocybin in addressing conditions such as chronic pain, cluster headaches, and even heart health.

        As research progresses, we may witness the development of innovative therapeutic protocols, including personalized treatment plans tailored to individual needs and preferences. Integration of psychedelic therapy into mainstream healthcare systems, alongside rigorous training for healthcare professionals, will be crucial to ensure safe and effective implementation.

        Ultimately, the future of psychedelic therapy holds the promise of profound transformation in how we approach mental health and well-being. By embracing the therapeutic potential of these substances with scientific rigor and compassion, we have the opportunity to revolutionize mental healthcare and improve the lives of countless individuals.

        Bupropion 101: A Beginner’s Guide

        Now, let’s switch gears and turn our attention to one current treatment for mental health conditions: Bupropion.

        What Is Bupropion?

        Bupropion belongs to the class of medications known as norepinephrine-dopamine reuptake inhibitors (NDRIs) and is the only NDRI sold on the market today.

        NDRIs are considered atypical antidepressants, meaning they don’t fall under any of the four main classes of antidepressants: selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), or monoamine oxidase inhibitors (MAOIs).

        Atypical antidepressants are often prescribed if other types of antidepressants have been ineffective, but they can be used as a first-line treatment as well.

        Unlike SSRIs and SNRIs, which primarily target serotonin and norepinephrine, bupropion primarily affects dopamine levels in the brain. Bupropion acts by inhibiting the reuptake of both norepinephrine and dopamine, offering a unique mechanism of antidepressant action.

        This distinctive mechanism of action distinguishes it from other antidepressants and makes it a valuable option for individuals who may not respond well to traditional antidepressant medications.

        What Is Bupropion Used For?

        Bupropion is primarily prescribed to treat depression and is FDA-approved for adult depression, seasonal affective disorder, and smoking cessation. Additionally, it can be off-label for conditions such as antidepressant-induced sexual dysfunction, ADHD, depression associated with bipolar disorder, and obesity.

        With that being said, bupropion is primarily used for the treatment of:

            • Depression: Bupropion works by increasing the levels of dopamine in the brain, which can help alleviate symptoms of depression such as persistent sadness, loss of interest in activities, changes in appetite or sleep patterns, and feelings of worthlessness or guilt.

              • Seasonal Affective Disorder (SAD): SAD is a type of depression that occurs at the same time each year, usually during the fall and winter months when daylight hours are shorter. Bupropion can help manage symptoms of SAD by regulating mood and energy levels.

                • Smoking Cessation: Under the brand name Zyban, bupropion has also been found to be effective in smoking cessation. Bupropion can help reduce nicotine cravings and withdrawal symptoms, making it easier for individuals to quit smoking.

              Bupropion in Numbers: Understanding the Statistics

              In the United States, mental illness affects approximately one in five adults, which is about 57.8 million individuals. Despite its prevalence, only around half of those affected receive some form of mental health treatment, including access to inpatient and outpatient services, counseling, or prescription medication.

              Depression was ranked as the single largest contributor to global disability by the World Health Organization (WHO) as it poses significant challenges for individuals worldwide. Its widespread impact underscores the urgent need for effective treatment options.

              When it comes to treatment, bupropion stands out as one of the most widely prescribed antidepressant medications globally. Recent statistics reveal its prominence as a top choice for healthcare providers when treating depression and other mood disorders.

              According to Definitive Healthcare, bupropion holds the position of the 5th most commonly prescribed antidepressant in the US, highlighting its widespread use and effectiveness in clinical practice.

              Top 10 Antidepressant Medications Dispensed in the US

              Rank Medication % of antidepressant prescriptions dispensed in US for 2022 User Rating % for Depression
              1 Sertraline (Zoloft) 13.1% 68%
              2 Escitalopram (Lexapro) 10.8% 72%
              3 Trazodone (Desyrel, Oleptro) 9.7% 66%
              4 Fluoxetine (Prozac) 8.8% 70%
              5 Bupropion (Wellbutrin) 7.9% 69%
              6 Duloxetine (Cymbalta) 7.2% 63%
              7 Quetiapine (Seroquel) 5.0% 64%
              8 Citalopram (Celexa) 4.9% 72%
              9 Venlafaxine (Effexor) 4.8% 60%
              10 Aripiprazole (Abilify) 3.7% 64%

              There has been an increase in the number of bupropion prescriptions in the US over the years. For instance, in 2004, 17.87 million bupropion prescriptions were prescribed, whereas 29.1 million prescriptions were prescribed in 2021.

              As we witness a rise in antidepressant prescriptions and mental health diagnoses every year, it becomes evident that alternative treatments are needed, as current ones may be inadequate.

              The Interaction Between Psilocybin and Bupropion

              Understanding the interactions between different substances in the brain is crucial for ensuring safe and effective psychedelic therapy. When combining psilocybin with medications like bupropion, it’s essential to consider how these substances may interact and influence each other’s effects, potentially impacting your overall experience.

              How Does Psilocybin Work in the Brain?

              Psilocybin’s effects stem from its interaction with serotonin receptors in the brain, particularly the serotonin 2A (5-HT2A) subtype. By acting as a partial agonist at these receptors, psilocybin triggers a series of neural responses, leading to shifts in perception, mood, and cognition.

              Furthermore, psilocybin influences neuroplasticity, the brain’s ability to reorganize and form new neural connections. This phenomenon allows for the adaptation and restructuring of neural circuits, potentially contributing to the therapeutic effects of psilocybin in conditions such as depression and anxiety.

              Additionally, psilocybin disrupts the default mode network (DMN), a brain network involved in self-referential thoughts and introspection. By reducing activity in the DMN, psilocybin may promote states of ego dissolution and interconnectedness, characteristic of the psychedelic experience.

              Recommended Reading: How do Psychedelic Drugs Work in the Brain?

              How Does Bupropion Work in the Brain?

              Unlike psilocybin, which primarily targets serotonin receptors, bupropion acts on multiple neurotransmitter systems in the brain. Its primary mechanism of action involves primarily blocking the reuptake of dopamine and norepinephrine, leading to increased levels of these neurotransmitters in the brain.

              Dopamine and norepinephrine are essential for regulating mood, motivation, and energy levels. When these neurotransmitters are not adequately regulated, it can contribute to mood disorders such as depression and anxiety.

              Bupropion’s inhibition of dopamine and norepinephrine reuptake helps to rebalance these chemical messengers, restoring normal function in the brain’s signaling pathways and alleviating symptoms of depression and other mood disorders.

              Exploring the Interaction Between Bupropion and Psilocybin

              Now that we have gained insight into the individual mechanisms of action of both psilocybin and bupropion in the brain, it’s essential to explore how they may interact when used together.

              Using antidepressants like SSRIs and SNRIs, which work on the serotonin receptors, in combination with psilocybin may blunt the effects of the psychedelic substance. Because bupropion targets norepinephrine and dopamine instead, psychedelic effects are unlikely to be diminished with this combination.

              “Yup. I’ve taken mushrooms on 300mg, 150mg, and 0mg of wellbutrin with similar effects. I find it slightly affects LSD trips, but only slightly.” – Reddit User

              In addition, there is no direct interaction between the metabolic pathways of these drugs. Bupropion is metabolized primarily by CYP2B6 in the liver to its active metabolites, while psilocin, the active compound derived from psilocybin, follows an entirely different metabolic pathway.

              To sum it up, bupropion and psilocybin have different primary mechanisms of action and do not directly compete at the receptor level. Therefore, it’s highly unlikely to experience any interactions when combining bupropion with psilocybin.

              However, it’s important to note that individual circumstances vary, so you should always consult with your healthcare provider before undergoing psychedelic therapy, as certain medications or health conditions have a higher chance of interacting negatively with psilocybin.

              “Wellbutrin is not an SSRI. My doctor gave me the go-ahead while I was taking Wellbutrin, bit it was a well-discussed and planned process to actually help me come off the Wellbutrin.

              If you can broach the subject of therapeutic uses of psychedelics, many mental healthcare professionals are actually very supportive of “off the record” use as long as your intended use is therapeutic in nature, they know you’ve done your research, and you have made arrangements for it to be a safe experience.

              Due to legality issues, they can’t officially condone or actively participate in your therapy, but it might be worth a discussion.” – Reddit User

              Other Factors That Influence the Psychedelic Experience

              As previously stated, each person is unique, and a psilocybin experience can affect one person in a completely different way than another. Beyond medication interactions, several other factors can influence the psychedelic experience.

                  • Set and Setting: The mindset and environment in which the psychedelic experience occurs can significantly impact its outcome. A supportive and comfortable setting, coupled with a positive mindset, can enhance the therapeutic potential of psilocybin.

                    • Supportive Guidance: Having an experienced psychedelic guide present during the psychedelic experience can provide reassurance and guidance, reducing the likelihood of challenging effects and maximizing therapeutic benefits.

                      • Dosage: The amount of psilocybin consumed significantly influences the psychedelic experience. Higher doses typically result in more profound effects, whereas microdoses generally produce subtle changes in mood and cognition without inducing full-blown psychedelic effects.

                        • Preparation: Mental and emotional preparation before a psychedelic experience can greatly impact its outcome. Practices such as setting intentions, creating a comfortable environment, and having a trusted guide present can enhance the experience and minimize the risk of negative outcomes.

                          • Integration: Following the psychedelic experience, integration practices such as mindfulness practices, guided discussions with a guide, and community support can help individuals process and integrate insights gained during the experience into their daily lives.

                        Considering these factors alongside potential medication interactions is essential for fostering safe and transformative psychedelic experiences. It’s crucial to approach psychedelic therapy with mindfulness, respect, and a commitment to promoting overall well-being.

                        Bupropion’s Influence on Psychedelic Experiences

                        Because bupropion and psilocybin work differently in the brain, it’s highly unlikely for them to interact, meaning the psychedelic experience is generally unaffected. However, individual responses can vary, so it’s essential to approach the combination of bupropion and psychedelics under the guidance of your healthcare provider and psychedelic guide.

                        “It’s safe and I feel like it can even be pretty good in counteracting the weird body load of shrooms. But it can also make stuff happen a little faster so watch for a speedy effect in the mindset that isn’t pronounced without the shroom combo.” – Reddit User

                        Do I Need to Stop Taking Bupropion Before Using Psychedelics?

                        With that being said, should you stop taking bupropion before undergoing psychedelic therapy?

                        The short answer is no; you do not necessarily need to stop taking bupropion before using psychedelics.

                        Unlike certain medications that have a higher chance of negatively interacting with psychedelics, bupropion is not known to pose a significant risk when combined with psychedelics like psilocybin.

                        However, the decision to continue or discontinue bupropion before using psychedelics should be made in consultation with a healthcare provider. Factors such as individual medical history, dosage of bupropion, duration of use, and reasons for the psychedelic experience should be carefully considered.

                        In fact, most psychedelic guides recommend against stopping bupropion before a psychedelic experience, as abruptly discontinuing medication can have adverse effects and may not significantly impact the psychedelic experience.

                        “If they’re on an antidepressant like Wellbutrin that has a low potential for interaction, I leave it to their discretion.” – Facilitator in Psychedelic Passage Network

                        Some individuals may choose to temporarily discontinue bupropion before a psychedelic experience to minimize any potential interactions and optimize the effects of the psychedelic. 

                        “I took 9g of mushrooms yesterday and did not feel the effects. It might be because of Wellbutrin but idk. I won’t bother trying again.” – Reddit User

                        However, abruptly stopping bupropion can lead to withdrawal symptoms or a recurrence of depression symptoms in some individuals. Therefore, if you decide to stop bupropion temporarily, it’s essential to do so under the guidance of a healthcare provider and with a tapering schedule to minimize withdrawal effects.

                        Recommended Reading: Psychedelics, Antidepressants, & Tapering – Spirit Pharmacist, Dr. Ben Malcolm

                        Unlike SSRIs and SNRIs, bupropion often causes fewer withdrawal effects or, in some cases, none at all. This is because of bupropion’s mechanism of action, as it primarily targets dopamine and noradrenaline rather than serotonin.

                        “No, I don’t believe that they have to come off their antidepressant before a journey although it is important to properly set expectations about the possible outcomes if they do choose to stay on them. I try to empower them to make the decision that they feel will be best for them.” – Facilitator in Psychedelic Passage Network

                        Ultimately, the decision to continue or discontinue bupropion before using psychedelics is a personal one that should be made based on individual circumstances, intentions, preferences, and medical advice. It’s crucial to prioritize safety, informed decision-making, and responsible use when combining medications and psychedelics.

                        Recommended Reading: Should I Stop Using Antidepressants For Psychedelic Therapy?

                        Survey Insights: Anecdotal Observations on Antidepressant Interactions

                        As we continue to learn more about the relationship between antidepressants and psychedelics, we conducted a survey among the psychedelic facilitators in our network at Psychedelic Passage. The goal of the survey was to collect firsthand experiences and observations about how different antidepressants interact with psychedelic substances.

                        In the survey, all facilitators agreed that interactions between bupropion and psilocybin are rarely problematic and typically don’t require tapering. This response differed from the responses for other antidepressants.

                        For instance, the responses to SSRIs varied, with most interactions being occasionally troublesome and tapering requirements being unpredictable, while a few indicated that the interaction almost always led to issues and required tapering.

                        The results of the survey highlight the unique nature of bupropion, which is less likely to interact significantly with psilocybin compared to other antidepressants. This suggests a safer approach when considering psychedelic therapy in conjunction with bupropion.

                        How Do Other Antidepressants Affect Your Psychedelic Experience?

                        In a world where mental health conditions are on the rise, understanding how different classes of antidepressants interact with psychedelics is crucial for ensuring a safe and meaningful psychedelic experience. This knowledge becomes particularly significant considering that it often takes trying a couple of different antidepressants before finding the right one.

                        In fact, there’s a 50% chance of finding the right antidepressant for you on the first try. However, if the initial medication doesn’t have the desired effect, the likelihood decreases to 40%  Therefore, each switch to a new medication slightly reduces the odds of finding the right one.

                        While bupropion is unlikely to cause interactions with psilocybin, other antidepressants may dampen or potentiate the effects of psychedelics or pose serious health risks when combined. Therefore, being informed about these interactions is essential for individuals seeking effective treatment options.

                        Complete List of Antidepressant Medication Names

                        Brand Name Generic Name Type
                        N/A (Formerly Elavil) amitriptyline Tricyclic
                        Wellbutrin, Zyban bupropion NDRI
                        Celexa citalopram SSRI
                        Pristiq, Khedezla desvenlafaxine SNRI
                        BuSpar buspirone Anxiolytic
                        Pamelor doxepin Tricyclic
                        Cymbalta duloxetine SNRI
                        Lexapro escitalopram SSRI
                        Prozac fluoxetine SSRI
                        Luvox fluvoxamine SSRI
                        Marplan isocarboxazid MAOI
                        Remeron mirtazapine Atypical
                        Pamelor nortriptyline Tricyclic
                        Paxil, Pexeva paroxetine SSRI
                        Nardil phenelzine MAOI
                        Emsam selegiline MAOI
                        Zoloft sertraline SSRI
                        Parnate tranylcypromine MAOI
                        Desyrel, Oleptro trazodone Atypical
                        Effexor venlafaxine SNRI
                        Viibryd vilazodone SSRI
                        Trintellix vortioxetine SSRI

                        Selective Serotonin Reuptake Inhibitors (SSRIs)

                        When SSRIs are combined with psychedelics, they can potentially dampen the psychedelic experience. This occurs because SSRIs block the reuptake of serotonin, increasing its levels in the brain. Because psilocybin also interacts with serotonin receptors, the abundance of serotonin can disrupt the binding of psychedelics to these receptors.

                        Recommended Reading: The Psilocybin-Blunting Effects of SSRIs and Antidepressants

                        As a result, the psychedelic effects may be reduced or altered, requiring higher doses to achieve the desired effects. Additionally, elevated serotonin levels increase the risk of serotonin syndrome.

                        Serotonin syndrome is a condition characterized by elevated serotonin levels in the brain. Symptoms range from restlessness and nausea to more severe manifestations like elevated blood pressure and rapid heart rate, and in severe cases, serotonin syndrome can be fatal.

                        “Prozac is an SSRI , which have been known to have nasty interactions with shrooms like serotonin syndrome; Wellbutrin doesn’t seem to have many interactions from everything I’ve read.” – Reddit User

                        “Lexapro 10000% affected my shroom trips! I never had a “real” trip until being off of lexapro for 2+ years. Being off lexapro and eating shrooms humbled me lol” – Reddit User

                        Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)

                        SNRIs work by blocking the reuptake of both serotonin and norepinephrine in the brain. Similar to SSRIs, SNRIs have the potential to diminish the effects of psychedelics because of their influence on serotonin levels. This occurs because SNRIs increase the availability of serotonin in the brain, which can interfere with the binding of psychedelics to serotonin receptors. 

                        Like SSRIs, the psychedelic experience may be dampened when SNRIs are combined with psychedelics.

                        “It will definitely dampen your trip hard! I take an Snri currently, at first I didn’t know the medication was an Snri, took mushrooms a couple times 3g+ and felt very little to nothing. Meanwhile everyone else on shrooms was having a fantastic time.” – Reddit User

                        Tricyclic Antidepressants (TCAs)

                        TCAs, like amitriptyline and nortriptyline, are older forms of antidepressants that mainly inhibit serotonin and norepinephrine reuptake in the brain. Unlike SSRIs and SNRIs, TCAs can heighten the effects of psychedelics and raise the risk of serotonin syndrome when combined with certain psychedelics.

                        Recommended Reading: The Psilocybin-Intensifying Effects of TCAs, MAOIs, & Antidepressants

                        “You should be fine, especially with such a small dose. I researched it thoroughly to make sure it was safe before I tripped and I’m 99.9% sure it’s perfectly fine. Serotonin syndrome is extremely unlikely from using mushrooms. (I’d say nearly impossible.) 

                        Also, Amitriptyline doesn’t really work on serotonin as much as you’d think. It increases norepinephrine levels more than anything. I’m on 30mg, which is triple your dose. I took 5 grams and tripped harder than I have ever tripped before. I’ve done 5 grams many times but have never had ego-death until that night haha.” – Reddit User

                        Monoamine Oxidase Inhibitors (MAOIs)

                        Combining MAOIs with psychedelics like psilocybin can pose serious risks. MAOIs work by inhibiting the enzyme responsible for breaking down neurotransmitters such as serotonin. As a result, serotonin levels in the brain can increase significantly, amplifying the effects of psilocybin and increasing the risk of serotonin syndrome.

                        Because MAOIs intensify the effects of psilocybin and heighten the risk of serotonin syndrome, they should never be combined with psychedelics.

                        “MAOI stands for MonoAmine Oxidase Inhibitor. They’re sometimes used as antidepressants but I suppose the drug scene is more familiar with them through Ayahuasca, which is a combination of a MAOI and DMT.

                        Yes, they do potentiate the effects of psilocybin mushrooms (and I suppose many other orally ingested psychedelics) because they inhibit enzymes in your stomach that would break amines down before they reach your bloodstream.

                        A word of caution though: you should watch your diet a few days before and after taking a MAOI, and definitely stay away from other drugs during that time.” – Reddit User

                        Navigating Interactions for Safe and Meaningful Journeys

                        When considering embarking on your psychedelic journey while taking antidepressants, it’s absolutely crucial to consult with your healthcare provider and psychedelic guide beforehand. 

                        This discussion will ensure that you have a thorough understanding of how your antidepressants may interact with psychedelics and what safety precautions you need to take. It’s essential to prioritize your well-being and make informed decisions to ensure a safe and beneficial experience.

                        A Guide to Psilocybin Mushrooms and Bupropion Interactions

                        Navigating the intricate interplay between bupropion and psilocybin offers insights into the potential impact of combining antidepressants with psychedelic therapy, empowering individuals to make informed choices for their mental health journey.

                            • Expert Guidance on Interactions: Gain valuable insights into the complex interplay between psilocybin mushrooms, SSRIs, and antidepressants with our comprehensive Interaction & Taper Guide, equipping you with the knowledge to navigate potential interactions and optimize your therapeutic journey.

                            • Insights from Experts: Listen to our podcast episode on SSRIs, Antidepressants, and Psilocybin, featuring discussions with our co-founders about the nuanced relationship between SSRIs, antidepressants, and the use of psilocybin.

                            • Expert Guidance on Tapering: Seeking advice on safely transitioning from antidepressants to engage in psychedelic therapy? Dr. Ben Malcolm, the Spirit Pharmacist, shares his expertise in Psychedelics, Antidepressants, & Tapering, offering strategies for tapering and mitigating withdrawal symptoms.

                          Ready to Find a Trusted Psychedelic Therapy Provider Near You?

                          Hi there! We sincerely hope that you’ve found valuable takeaways that resonate with your current intentions. To explore research-based education, stay updated with psychedelic news, and benefit from practical how-to articles, we encourage you to head over to our resources page.

                          If you’re seeking personalized advice and are prepared to take the first step toward a therapeutic psychedelic experience, we invite you to book a consultation with our team of experienced psychedelic concierges.

                          This consultation is more than just a conversation; it’s an opportunity to be matched with a trustworthy local facilitator. You’ll be seamlessly connected to our rigorously vetted network of psychedelic guides, ensuring potential matches align with your needs.

                          Psychedelic Passage offers confidence and peace of mind by alleviating the burden of having to guess who’s right for you. If you want to discover how Psychedelic Passage can help you, we empower you to learn more about our services and check out client testimonials from those who’ve gone before you.

                          Your healing path is uniquely yours, and our commitment is to serve you at every juncture. Psychedelic Passage: Your Psychedelic Concierge — The easy, legal way to find trustworthy psilocybin guides, facilitators and psychedelic-assisted therapy near you in the United States.

                          Learn More About Our Network

                            Connect with Psychedelic Passage

                              Frequently Asked Questions About Psilocybin and Bupropion Interactions

                              1. What if I decide to stop taking bupropion for my psychedelic experience?

                              If you’re considering stopping bupropion for a psychedelic experience, it’s crucial to consult with your healthcare provider. Abruptly discontinuing bupropion may lead to withdrawal symptoms or a resurgence of depression symptoms. Your healthcare provider can guide you through a tapering schedule to minimize these risks.

                              2. Will the length of time I’ve been on antidepressants affect my psychedelic experience?

                              The duration of your antidepressant use might influence your psychedelic experience, as long-term use can potentially impact neurotransmitter levels and neural pathways. However, individual responses vary, and it’s essential to discuss any concerns with your healthcare provider before undergoing psychedelic therapy.

                              3. Do different ways of taking antidepressants, like pills or extended-release forms, change how they interact with psilocybin?

                              The method of administering antidepressants, such as pills or extended-release formulations, may affect how they interact with psilocybin. The method of administration of antidepressants can affect their absorption rate, metabolism, and overall bioavailability in the body.

                              4. Would the dosage of my antidepressant impact my psychedelic experience?

                              The dosage of your antidepressant could potentially impact your psychedelic experience, as higher doses may alter neurotransmitter levels in the brain. However, individual responses vary, and it’s essential to discuss any concerns or adjustments with your healthcare provider before engaging in psychedelic therapy.

                              5. Can psilocybin therapy help if regular antidepressants haven’t worked for me?

                              Psilocybin therapy may offer an alternative for individuals who have not found relief with traditional antidepressants. However, the effectiveness of psychedelic therapy can vary depending on individual circumstances and the underlying causes of depression.

                              It’s essential to work with a qualified psychedelic guide to explore treatment options tailored to your specific needs and preferences.


                                  1. Fava, M. (2008). Norepinephrine-dopamine reuptake inhibitor. Norepinephrine-Dopamine Reuptake Inhibitor – an overview | ScienceDirect Topics.
                                  2. Geiger, H. A., Wurst, M. G., & Daniels, RN. (2018, Jul 16). Dark classics in chemical neuroscience: Psilocybin. ACS chemical neuroscience.
                                  3. Huecker, M. R. (2023, April 9). Bupropion. StatPearls [Internet].
                                  4. Kumar, S., Soren, S., & Chaudhury, S. (2009, July). Hallucinations: Etiology and clinical implications. Industrial psychiatry journal.
                                  5. MacCallum, C. A., Lo, L. A., Pistawka, C. A., & Deol, J. K. (2022, December 1). Therapeutic use of psilocybin: Practical considerations for dosing and administration. Frontiers in psychiatry.
                                  6. U.S. Department of Health and Human Services. (n.d.). Mental illness. National Institute of Mental Health.
                                  7. Watson, S. (n.d.). Depression: Finding what works for you. WebMD.
                                  8. WebMD. (n.d.). Norepinephrine and dopamine reuptake inhibitors (ndris): Side effects, interactions, and more. WebMD. 


                                Looking for a professionally supported in-person psychedelic experience?

                                Take the first step and book a consultation call with us today. We'll walk you through every step of the process after getting to know you and your unique situation.

                                Related posts

                                At Psychedelic Passage, we offer professional 1-on-1 guidance and companionship on your journey of healing. We simply can't sit back and let Americans continue to sit in silent suffering trying to battle mental health issues within a broken health care system, all while knowing that effective alternatives exist. We stand for the sacred, at-home, ceremonial use of psychedelics for consciousness exploration, which we believe to be a fundamental human right.


                                Search for anything like: microdosing, dosage, integration

                                Get Your Free Psilocybin Sourcing Guide!

                                Just tell us where to send it…

                                Download Our Free Psilocybin Sourcing Guide!

                                For harm-reduction purposes, we provide links to online psilocybin vendors, local stores, delivery services, and spore vendors for growing your own medicine at home.

                                Congratulations! We've sent the sourcing guide to your inbox. 

                                You can now close this window.