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Psychedelic Dosage Guide: How Much of Each Substance to Take

Nicholas Levich
Nick is one of the Co-Founders of Psychedelic Passage. As a facilitator himself, he draws upon his personal experience as well as scientific literature and anecdotal reports when writing. His goal is to provide tangible and actionable advice to readers looking to establish healthy and intentional relationships with psychedelic medicines.

Alongside other questions about psychedelics, many people commonly wonder which substances to take and what a proper therapeutic dose looks like. Unlike commercialized drugs that come in uniform sizes like prescription medication, cigarettes, and beer, it’s more difficult to find a ‘standard’ dose of a psychedelic substance. 

Psychedelics affect people in different ways and it’s important to realize that even the same dose of the same psychedelic drug at different times can produce entirely different experiences—even for the same person. 

Although the variety of experiences do make psychedelic dosages somewhat difficult to quantify, we have experiential, anecdotal and scientific information to help decide proper dosage amounts. 

While recent research has discovered certain dosages can contribute to positive effects, the responsibility of determining a safe and sufficient dosage for your experience will ultimately fall on you. 

What You’ll Need to Determine an Accurate Dosage

1. Drug Purity Test Kit

It is absolutely essential that you know what substance and mushroom species you’re ingesting. When it comes to staying safe and supporting your journey with psychedelics, a drug testing kit is your best friend.

Luckily, we’ve dedicated an entire article to reviewing the best psychedelic purity test kits. In it, we review DanceSafea unique organization that offers reagent test kits for psychedelics as well as providing education and harm reduction services to its community. 

They are dedicated to promoting health and safety within the music and nightlife communities and have a strong emphasis on education and harm reduction. DanceSafe sells an MDMA Testing Kit, an LSD Testing Kit, and a Ketamine Testing Kit

Dance Safe Psychedelic Purity Test Kit

Their Standard Set of 6 Reagents is also a best seller. This set tests for MDMA, ketamine, and LSD. Dance Safe offers workshops, training sessions, and outreach programs to promote harm reduction and provide their community with the tools they need to make informed decisions about substance use. 

Dance Safe Psychedelic Test Kit

They also actively engage with their community, gathering feedback and using it to continuously improve their services and offerings. If you are looking for a reagent test kit provider that prioritizes education, harm reduction, and transparency, DanceSafe is the perfect choice. 

2. High-quality Scale

Investing in a high-quality scale is crucial. Aside from LSD, including fresh mushrooms and dried magic mushrooms can be weighed. When it comes to certain substances (like DMT), even a slight change in weight can have a huge impact, so it’s important that you can ensure you’re taking the correct amount.

3. Drug Potency Test Kit

Unlike traditional reagent kits that merely identify the presence of a substance, potency tests go a step further by revealing the potency of psychoactive compounds in milligrams or as a percentage. 

By providing quantitative data on the potency of psychoactive substances, these kits enable users to accurately determine the exact dosage of the most popular psychedelic drugs. 

In a groundbreaking development for harm reduction practices, Dr. Felix Blei, based in Jena, Germany, has pioneered QTests—the world’s first quantitative reagent test kits specifically designed for psychedelics. 

The introduction of QTests revolutionizes the way individuals approach harm reduction in the realm of psychedelics. Qtests offers an MDMA test kit, LSD test kit, psilocybin mushroom test kit, and even a cannabis test kit.  

QTests provide a scientifically validated method for determining the concentration of unregulated substances, granting both journeyers and healthcare providers greater control over treatment processes and enhancing the potential benefits of psychedelic therapies. QTest Potency of Psychedelics

Psychedelic Dosages Compared to Other Drugs

While we’ve come a long way in terms of research and regulation, we’ve only just begun to dip our toes into the psychedelic pool. Whereas specific dosages and recommendations can be made for other drugs (tobacco, alcohol, etc.), medical guidance and safety protocols still fall behind when it comes to psychedelics. 

Prohibition has ultimately caused the safety and efficacy of psychedelics to fall into the hands of the users themselves. With future legislation and legalization, that may change. 

But for now, the best way for users to stay informed and practice harm reduction is with the help of a psychedelic facilitator who provides preparation, trip sitting, and integration services throughout your journey. 

If you’re interested in this type of support and want to receive personalized guidance on how to get the most out of your psychedelic experiences, we invite you to book a consult with our psychedelic concierges today. Our concierges will help you get connected to our pre-vetted network of psychedelic facilitators, located around the country.

In the meantime, we’ve put together this comprehensive psychedelic dosage guide based on each type of substance. This guide will help you determine how much of each substance to take for your desired effect. We’ll state our recommended dose as well as what a light and a heavy dose would look like for reference.  

Determining Therapeutic Dosage: Psychedelic or ‘Magic’ Mushrooms

Recommended Dosage: 20 to 30 mg of psilocybin/70 kg of body mass (typically equates to about 3 to 5 grams of dried mushroom)

It’s important to note that much of the research on taking magic mushrooms has involved the active chemical compound itself—not the entire mushroom. Determining mushroom dosage typically involves the mushroom as a whole. 

Furthermore, different psychedelic mushrooms or magic mushrooms contain different amounts of psilocybin, the ingredient that makes you “trip.” If you’re going to use a recommended dosage, you’ll have to do some math to work the weight of the mushrooms required to contain the amount of recommended psilocybin (mg). 

Fortunately, there are a few calculators that can help determine low dose and high dose amounts for dried mushrooms: this calculator allows you to choose from fresh or dried mushrooms or truffles, and this one breaks it down into different strains of mushroom and considers if you’re taking a monoamine oxidase inhibitor (MAOI) or not.

Generally speaking, higher doses, which some call a heroic dose of psilocybe mushrooms are associated with more positive benefits. However, as with most substances, this is a very fine line and higher doses don’t always translate into better experiences. 

A higher, heroic dose of fresh mushrooms will almost always result in a more intense experience, which can result in significant discomfort–what many categorize as a ‘bad trip‘.  It’s also important to note that even the lowest dosages used in these studies produce long-lasting and positive changes in spiritual beliefs, overall satisfaction, behavior, and attitudes. 

This supports the idea that both microdosing (taking a small amount that doesn’t make you hallucinate) and macrodosing (taking an amount that kicks off a full blown psychedelic trip) provide benefits. With that being said, if you’re experimenting with psilocybin for the first time, start small. 

Research Studies on Therapeutic Psilocybin Dosages

51 Cancer patients were given either a very low dose (1-3 mg/70 kg) or a  of magic mushrooms to study the effects of potentially decreasing depression associated with life-threatening illnesses. The high dose cases reported decreases in and anxiety. 

Another study investigated headaches (which are commonly reported with magic mushrooms) and reported that the duration, severity, and incidence all increase with the dosage amount (5, 10, 20, and 30 mg/70 kg).

Mystical-type experiences are generally reported with higher doses of psilocybin. Perceptual effects began at around 20 to 30 mg/70 kg dosages. These higher doses also attributed to longer-lasting benefits in behavior, mood, attitudes. They also contributed to “substantial personal and spiritual significance,” with the highest dose producing the greatest positive effects. 

It’s important to realize that sometimes, even “bad trips” produce the most benefits in the long run. In one study, a volunteer was given the highest dose (30 mg/70 kg) and reported that it was the worst experience she had ever encountered. 

Although she almost dropped out of the study, she ended up continuing to participate and actually re-evaluated her first experience as one with spiritual significance with life satisfaction and well-being benefits. She then rated her second encounter as the number one most personally meaningful and spiritually significant experience of her life.

While genuinely “bad” trips are with magic mushrooms are possible, especially with higher doses, it’s helpful to know that there are tools that can help mitigate bad trips and transform them into experiences with significant insight and meaning. 

Feeling supported in your journey with magic mushrooms is undoubtedly the best way to prevent truly bad trips, and to turn them into meaningful experiences. Seeking support from a psychedelic guide who also offers integration services is essential to accessing and implementing the insights received in a magic mushroom experience, especially the tough ones. 

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Determining Therapeutic Dose: Lysergic Acid Diethylamide (LSD)

Recommended Dosage: 50 – 150 µg (micrograms) per individual, 200+ µg in highly supportive settings

LSD also has unique characteristics that make it somewhat difficult to dose. Unless you have a direct connection to the illicit source or are able to access LSD in liquid form, you probably won’t know how much you are taking. 

That’s because the most common form of LSD comes on blotter paper, which is an absorbent paper soaked in a solution of LSD. An average sheet of blotter paper has about 100 uniform tabs containing about 100 µg per tab. 

However, unless you know who’s prepared the blotter sheet, it’s difficult to know how much LSD each tab or hit will contain. In other words, one piece of blotter paper could contain 100 µg and another tab of the exact same size could contain 200 µg. 

That said, it’s important to exercise caution when it comes to LSD, as even with the most trustworthy sources, you may be consuming an unknown amount. 

Research Studies on Therapeutic LSD Doses

The minimal recognizable dose of LSD is about 25 µg. A moderate dose (75 to 150 µg) will result in a significantly altered state of consciousness and is commonly associated with euphoria, increased introspection, pseudohallucinations, changes in ego-function, and alterations of thinking and time experience. This makes LSD difficult to microdose (we prefer psilocybin for microdosing). 

A full LSD reaction typically occurs at doses of around 100 to 200 µg. At the higher end (200 µg), mystical experiences are typically reported, and this dose is associated with benefits for depression, anxiety, and substance use disorder. Compared to a 100 µg dose, 200 µg produces greater feelings of openness, trust, happiness, and closeness to others. 

A typical experience will last eight hours on average. Residual effects can last for over 12+ hours after ingestion. Doses of more than 100 µg produce psycho-sensory effects like increased sensory perception, synesthesia, and enhanced mental imagery.

It is also associated with weakened ego identification. A 200 µg dose is not associated with acute or chronic adverse effects and has been attributed to reductions in anxiety for up to 12 months. Interestingly, the 200 µg dose was associated with less anxiety during the experience than what was reported with the placebo.

Traumatic experiences or “bad trips” with LSD are possible, and they can contribute to long-lasting effects. These are most commonly reported when LSD use takes place in uncontrolled conditions. If you need support integrating a challenging LSD experience, we encourage you to connect with our network of pre-vetted psychedelic integration specialists today. 

In a safe and supportive environment, even extremely high doses of LSD may produce long-lasting positive effects. In fact, in the case of three accidental LSD overdoses, positive mental and physical health effects were reported. 

Determining Therapeutic Dose: MDMA or ‘Molly’

Recommended Dosage: 3 mg per kg of body mass, or 60 to 150 mg (dependent on weight and sensitivity) 

Pure MDMA itself is a very safe drug and presents less danger than other substances like alcohol and tobacco. It’s rarely habit-forming and has a smaller risk of death than horse riding. However, MDMA does present great risk to those who use it when it contains other substances. 

Due to a lack of regulation and safety protocols for the illicit substance, the black market has become a place where dangerous variants are sold as MDMA, which is why drug testing kits are vital to risk mitigation and safety. MDMA typically comes in the form of a powder or pressed pill and these testing kits will help you determine whether any additives or harmful chemicals are in your substance. 

Regardless of what form MDMA comes in, the responsibility ultimately falls into the hands of the user. Again, it is highly recommended that you purchase a drug testing kit and test any substance you plan on consuming. 

Research Studies on Therapeutic MDMA Doses

Low doses (50 to 75 mg) are physiologically and psychologically safe, with greater efficacy (reductions in anxiety, depression, phobias, damaged self-esteem) reported for the higher dose (75 mg). No adverse side effects were reported at these dosages. 

Regular doses of MDMA (80 to 150 mg) produce euphoria, enhanced sensations, and increased empathy and energy—however, they can also produce adverse physiological effects like tremors, nystagmus, nausea, and elevated heart rate and blood pressure. Effects typically last three to five hours. 

Positive effects are typically reported up to doses of 100 mg, with higher doses associated with more negative effects. Doses of 180 mg or more associated with only negative effects. Higher doses are also associated with sleep loss and some effects on psychomotor function. 

The safety of MDMA has been demonstrated in recent clinical trials, particularly those who have reported its efficacy at reducing symptoms of PTSD. However, most recreational MDMA use involves other substances and consuming it at much higher doses than recommended. 

These have both been associated with the increase of MDMA-related deaths and are something to be wary of if you plan on consuming MDMA (reminder: test your substances and use a scale)

For many, these numbers, calculations, and recommendations are confusing. It can sometimes be a lot to process, but getting a dosage right is a pretty crucial component of psychedelic safety. 

Determining Therapeutic Dose: N,N-Dimethyltryptamine (DMT)

Recommended Dosage: 20 to 40 mg (smoked), or 0.2 to 0.4 mg per kg of body mass (intravenous infusion)*

*Please note that in clinical research, DMT is typically given intravenously, so these numbers should be considered to reflect that route of administration. 

DMT is one of the most powerful psychedelic compounds in the world producing a short, but extremely intense experience. DMT can come in the form of crystalline powder, suspended in a liquid, or infused with herbs (Changa). When used recreationally, DMT is typically smoked or vaporized. It is consumed at a single time (the whole dose in one hit). 

DMT is also the main psychoactive ingredient in Ayahuasca, a hallucinogenic herbal brew that has been used in sacred religious ceremonies of indigenous peoples of South America for generations. However, odds are if you live in the United States, these religious ceremonies will be illegal and not readily available. 

This is not a psychedelic substance to be taken lightly. Despite its short duration, the experience often results in overwhelming visual phenomena, ego-dissolution, and impaired motor function. As with other substances, start small and gauge your tolerance before you try a larger dose.

Research Studies on Therapeutic DMT Doses

Higher intravenous doses (0.2 to 0.4 mg/kg) were associated with brightly colored visuals, a brief loss of control, and an overwhelming rush before a dissociated state (where both anxiety and euphoria were reported). Lower doses (0.05 to 0.1 mg/kg) were ironically associated with less desirable effects. 

Recreational doses of smoked DMT are usually around 40 to 50 mg but can reach upwards of 100 mg. Higher doses are associated with sensory alterations. Lethality hasn’t been reported, even with extremely high doses. 

Near-death experiences have been associated with positive and long-term changes in psychological health and well-being and have been reported with various doses of DMT (7, 14, 18, 20 mg intravenous solutions).  

Determining Therapeutic Dose: Ketamine

Recommended Dosage: 25 to 100 mg (dependent on route of administration and your intention/goals)

Ketamine has historically been used as an anesthetic for medical procedures and surgery. However, recent alternative applications have produced positive results in addressing symptoms of anxiety, PTSD, and treatment-resistant depression. 

However, it is important to note that ketamine is typically administered via intravenous infusion, intramuscular injection, or oral lozenge in legal clinical settings; whereas illicit forms of ketamine typically come in a powder that is insufflated (snorted). 

The difference in administration methods change the recommended dosage. And as always, use a drug testing kit and scale to reduce the chance of adverse reactions. 

Research Studies on Therapeutic Ketamine Dose

A typical recreational dose is 50 to 100 mg (intravenously), 75 to 125 mg (intramuscularly), 200 to 300 mg (orally), or 60 to 250 mg (nasally). At lower doses, “heart opening” effects are experienced, like euphoria, compassion, peace, and pain relief. Medium doses produce out-of-body experiences and large doses can simulate a near-death experience or a complete loss of self. 

The average lethal dose is 600 mg per kg of body mass, or 4.2 g for a 70 kg (154 lbs) human. At lower amounts, overdose can cause symptoms like hypertension, abdominal pain, vomiting, impaired consciousness, excessive salivation, and chest pain. 

Long-term use of ketamine has been associated with severe urinary tract problems and episodic and semantic memory impairments. Unlike other psychedelics, ketamine has been associated with the development of tolerance and psychological dependence. 

However, it’s important to note that emergencies and death are extremely rare with ketamine and when these do happen, it’s typically because ketamine is used in conjunction with another substance. 


Determining Therapeutic Dose: Cannabis

Recommended Dosage: 66 to 800 mg (smoked), 5-25mg starting dose (ingested)

A standard recommended dosage for cannabis is extremely difficult to gauge. Different strains contain different combinations of cannabinoids (particularly THC and CBD) and terpenes (that control the effect of the high) which makes it difficult to quantify the proper dose. 

In addition, an individual’s tolerance will impact how they feel when using cannabis, and the various methods of use impact the human body differently. Smoking produces a quicker, shorter high, while edibles produce a long-lasting high that can take a few hours to feel. 

Even different inhalation methods, whether it be a joint, pipe, or vaporizer cartridge, will burn the THC in different ways, meaning that different amounts will make it into your body. Some scientists are pushing for a ‘standard’ dose of 5 mg THC. 

If you have access to testing results such as cannabinoid percentage, a calculator can help determine how much cannabis (THC) you’ll consume, but you’ll obviously have to experiment to determine what dosage is best for you. 

Research Studies on Therapeutic Cannabis Dose

Different doses are used for different medicinal goals (i.e. 5 mg for glaucoma, 5 to 7.5 mg for HIV/AIDS symptoms, 2 to 5 mg for seizures). The route of administration matters: 1 mg of Delta-9-tetrahydrocannabinol (THC) in an edible product is roughly the equivalent of 5.71 mg of THC in smokable cannabis. 

The “entourage effect” (i.e. the effect of tens, if not hundreds, of cannabinoids and other constituents present in the plant that increase in strength when combined, think of it as synergy) can produce different effects and modulate the “high” produced by THC. 

For cancer patients, pain relief is reported at doses of 400 mg of smoked dried cannabis. Subjective ratings of marijuana (a particular study used terms such as “strength,” “good effect,” “take again,” “high”) are not dose-dependent.

Even within one type of route of administration, such as smoking, the dosage will be influenced by a variety of factors (number, spacing, and duration of puffs, inhalation volume, hold time, etc.)

Knowing the THC and CBD content is vital information for users. Yet cannabis is more complex than that and we still have a long way to go. The cannabis plant hasn’t been recognized by the FDA, and labeling is not yet consistent across legalized states.  

Recommended Dosage is Not One Size Fits All

Because of the social and political stigma of psychedelics in the United States, there isn’t much actionable guidance on what the correct dosage is for your unique body and intended outcome. This means that when it comes down to it, your experience with psychedelics will be exactly that, yours

While anecdotal and scientific evidence can help you make decisions when it comes to dosage amounts, what works best for you will ultimately require some experimentation on your end. In order to find the optimal amount of any substance, you should always start small. 

While sometimes, higher doses result in “more enlightening” experiences, this isn’t always the case. In the same vein, overconsumption can be extremely uncomfortable. Just remember: you can always take more, but you can’t take less. 

You’ll want to find a dose that works best for you and your desired outcome. While you can read every scientific journal article and forum response out there, you’ll have to determine your own guidelines for your psychedelic use. Your tolerance and response to each substance will be unique, and psychedelic safety will ultimately be up to you. 

Speak With a Trusted Psychedelic Guide

Hi there! We sincerely hope that you’ve found valuable takeaways that resonate with your current intentions. To explore research-based education, stay updated with psychedelic news, and benefit from practical how-to articles, we encourage you to head over to our resources page.

If you’re seeking personalized advice and are prepared to take the first step toward a therapeutic psychedelic experience, we invite you to book a consultation with our team of experienced psychedelic concierges.

This consultation is more than just a conversation; it’s an opportunity to be matched with a trustworthy local facilitator. You’ll be seamlessly connected to our rigorously vetted network of psychedelic guides, ensuring potential matches align with your needs.

Psychedelic Passage offers confidence and peace of mind by alleviating the burden of having to guess who’s right for you. If you want to discover how Psychedelic Passage can help you, we empower you to learn more about our services and check out client testimonials from those who’ve gone before you.

Your healing path is uniquely yours, and our commitment is to serve you at every juncture. Psychedelic Passage: Your Psychedelic Concierge — The easy, legal way to find trustworthy psilocybin guides, facilitators and psychedelic assisted therapy near you in the United States.

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