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The Best Mushroom Strain For Psilocybin-Assisted Therapy

You’ve likely heard about the therapeutic benefits of psilocybin therapy, perhaps through ‘magic’ mushrooms mentions of  pen names like ‘shrooms’. But, did you know that there’s over 180 psilocybin mushroom species that could occasion your consciousness-expanding journey through space and time? 

Though some may be more readily accessible than others, each of these species comes equipped with their own visually-cadent spirit of hallucinogenic ascent. Whether you’ve stumbled across this page to ID a batch of these medicinal fungi teachers or to choose a strain that most closely resonates with your therapeutic psychedelic intentions, you’ve nevertheless come to the right place. 

Today, we’ll be diving head-first into the exquisitely unique properties of some of the most popular therapeutic mushroom strains on the market, including their trademarked shapes, gill structures, and most importantly, their healing effects. However, we want to note that the strain of your psychedelic mushroom medicine is ultimately of not too much importance. 

You can have an incredibly therapeutic experience on any one of these strains. It’s really your healing intention and ability to surrender that sways the prognosis of your trip. However, psychedelic research institutions suggest that knowing the strain you have could definitely be of value to psychedelic therapy, in order to make more educated decisions on dosage and psychedelic safety.

Download Our Free Psilocybin Sourcing Guide

For harm-reduction purposes, we provide links to online psilocybin vendors, local stores, delivery services, and spore vendors for growing your own medicine at home.

Beyond The Veil: A Journey Through Psilocybin Mushroom Strains

As we begin our exploration of psilocybin mushroom strains and their unique considerations, keep in mind the following list of articles in our Psilocybin Mushroom Strain blog series

Each of them are designed to target different aspects of psilocybin mushroom strain to demystify this part of psychedelic therapy and get your real answers, aiming to provide genuine insights rather than simplified responses.

1. Psychedelic Mushroom Strains by Potency: 30 Popular Varieties 

A myth-busting exploration of 30 popular psilocybin mushroom strains, offering pictures, experimental data on their potency, anecdotal reports, and links to purchase each.

2. Can Psilocybin Mushroom Strain Predict Effect Differences?

We examine strain-related effects through anecdotal experiences, Reddit discussions, and scientific perspective. Is a cube(nsis) really just a cube(nsis)?

3. How to Choose a Mushroom Strain for Psychedelic Therapy

A practical guide on selecting a mushroom strain, infused with beginner-friendly Reddit advice, covering therapeutic approaches, dosing intentions, factors like accessibility, consistency, and more.

4. Currently Reading: The Best Mushroom Strain for Psilocybin-Assisted Therapy

We discuss various strains of psilocybin mushrooms for therapeutic use, highlighting their unique properties, cultivation methods, alongside guidance on safe sourcing and therapeutic use.

The Therapeutic Benefits of Magic Mushrooms

Magic mushrooms have been used for thousands of years for their therapeutic and spiritual benefits. Recent studies have shown that these mushrooms have a profound impact on mental health, with promising results for treating anxiety, depression, and addiction.

Psilocybin, the psychoactive compound found in magic mushrooms, activates serotonin receptors in the brain, which can have a profound impact on mood and perception. Research has shown that psilocybin can reduce activity in the default mode network, a cluster of brain regions that are active when we are focused on ourselves and our own thoughts. 

This reduction in activity can lead to a sense of unity and interconnectedness with the world around us, which can be particularly helpful for those struggling with feelings of isolation or disconnectedness.

One of the most promising applications of psilocybin is in the treatment of depression. A 2016 study found that psilocybin-assisted therapy was effective in reducing symptoms of depression in patients who had not responded to traditional treatments. 

The study found that the therapeutic effects of psilocybin lasted for up to three months after the treatment, suggesting that it has long-lasting benefits. Psilocybin has also shown promise in the treatment of addiction

A 2018 study aimed to assess the long-term effects of psilocybin-facilitated smoking cessation treatment in combination with cognitive behavioral therapy (CBT). The results of the study showed that 67% of participants were confirmed as smoking abstinent at 12-month follow-up and 60% at long-term follow-up (≥16 months after psilocybin administration). 

Additionally, 86.7% of participants rated their psilocybin experiences among the 5 most personally meaningful and spiritually significant experiences of their lives. These findings suggest that psilocybin may be promising in promoting long-term smoking abstinence and add to the historical evidence suggesting high success rates when using classic psychedelics in addiction treatment.

It is important to note that psilocybin should only be used under the guidance of a trained professional, as it can produce intense and unpredictable effects. However, with proper guidance, magic mushrooms can be a powerful tool for healing and personal growth.

Therapeutic Psychedelic Mushroom Species & Strains

Magic Mushrooms: Psilocybe Cubensis

Psilocybe cubensis strains are probably the image that comes to mind when we think of therapeutic psychedelic mushrooms. These sacred fungi belong to the family of Hymenogastraceae and have appropriately gained the nickname “golden halos” for their almost-unmistakeable convexes or flat, yellow-brown caps and smooth, sticky surface. 

Psilocybe cubensis mushroom

Local to the tropics of Gulf Coast states, “cubes” are amongst the most widely distributed species because of their easy-to-cultivate properties, naturally germinating in cattle dung and grown indoors with substrates like coffee or brown rice flour. 

These medicinal fungi often bruise blue due to oxidation, with narrow gray gills edged by an off-white color, typically containing 10-12 mg of psilocybin per gram of dried mushrooms. Mostly odorless and with a ringed stipe, P. cubensis has been the lucky subject of much selective breeding, yielding over 60 divergent strains like Wavy Caps and Penis Envy. 

Fresh Psilocybe cubensis mushroom

The result? Carefully curated hybrid species of mushrooms whose desired characteristics have been isolated to produce heightened hallucinogenic effects and better adaptation to unpredictable environmental conditions. 

Psilocybe cubensis can be differentiated from its derivative counterparts by their commensurately large stem size and widened caps. Now let’s explore the extensive genetic analogs of these psychedelic mushrooms.

Magic Mushrooms: ‘Golden Teacher’

‘Golden Teacher’ is amongst the most favored strains of therapeutic psychedelic mushrooms. Their beautifully plump, smooth-to-the-touch caps produce a tinge of burnt-orange that fades into a slightly paler, somewhat-girthy stem. Journeying with Golden Teachers will take you along for a very introspective ride. 

Dried golden teacher mushroom

This cultivar is considered to be medium-strength in terms of potency, scaling in with 0.63% psilocybin, 0.60% psilocin, and 0.25% baeocystin, and with a shorter than average trip duration of 2-4 hours, making it a perfect strain for the not-so-experienced journeyer. However, the healing powers of these tough, little mushrooms should not be overlooked. 

Fresh golden teacher mushroom

In fact, Golden Teachers make their claim to fame by depositing a palpable sense of ancient intelligence through consoling feelings of heart-centered warmth and love. A sense of educational clarity is often reported with their experiences, offering the perfect balance of consciousness expansion and euphoric enjoyment.

Magic Mushrooms: ‘Albino Goodies’

‘Albino Goodies’ or albino mushrooms are a cross between the strains Golden Teacher and Albino A+ (AA+). They’re often deemed one of the most potent strains of cubensis and this popular speculation comes from the assumption that AA+ is biochemically similar to Panaeolus, which would explain why their potency is so highly sought-after (0.75% – 2%). 

This dynamic combination carefully extracts the unreserved wisdom, deeply reverenced in Golden Teacher strains, to produce revelatory experiences that employ the reportedly quicker-acting, physically-racing intensities of AA+. 

Dreid Albino Goodies mushroom

Though the name suggests AA+ is albino, their cream-colored fruiting body falls more in par with a leucistic denomination, showing visible signs of reduced pigmentation. When crossed with Golden Teachers, these ghostly mushrooms showcase a slightly more sun-kissed cap, favoring a minimal amount of light and propagating a focus on physical sensations, or what some would call a “body high”.

Magic Mushrooms: ‘Flying Saucers’

Psilocybe azurescens, aptly tagged ‘Flying Saucers’, are a relict therapeutic strain of P. cubensis that are thought to have been discovered in 1979 by a group of Boy Scouts wandering the forested grounds of Oregon state. Later, American mycologist, Paul Stamets, was the first to name and identify this strain in 1996.

Dried Flying Saucer Mushroom

Though the slick-looking, rusty-orange flesh of this strain is known to produce 25 mg of psilocybin for every dried gram (4x more potent than than p.cubensis), the Oregon Psilocybin Advisory Board suggests these mushrooms be avoided if their source is unknown, due to several reports of induced wood lover’s paralysis

This condition can cause prolonged muscle weakness and is associated with other mushrooms that grow in decaying wood, like P. stuntzii, P. alennii, and P. Cyans. 

Fruiting Flying Saucer Mushroom

However, plenty of anecdotes report a pleasantly potent therapeutic psychedelic experience on this strain, with no negative side effects. The best way to ensure a safe experience with the most potent strain of psilocybin mushrooms, is ensuring that your supply was sourced from an indoor cultivator, using wood chips or sandy soil substrates.

Magic Mushrooms: ‘Knobby Tops’

Ranking in as the second most potent strain of therapeutic psilocybin mushrooms are Knobby Tops, or Psilocybe Baeocystis. With 15 mg of potency for every gram of dried mushrooms, these mulch-loving fungi express a strong attachment to the bark of Douglas firs. First discovered in Oregon, these gelatinous mushrooms showcase a purple-brown spore print with a relatively thin, white-colored stem. 

Dried Knobby Top Mushroom

Mushroom fanatics use several names to reference this strain, including ‘bottle caps’, ‘blue bells’, or ‘olive caps’. Reports suggest that the psychoactive properties of Knobby Tops produce a higher-than-average intensity of colors, making this an ideal strain for the bravest, most thrill-seeking psychonauts.

Magic Mushrooms: The Bohemian Psilocybe 

Bohemian Psilocybe or Psilocybe Bohemica yields a whopping 15 mg potency per 1 gram of dried mushrooms, making these the third most potent strain of magic mushrooms. This fierce strain of psilocybin is native to central Europe and can be found making its annual debut during the autumn season. They have a particular affinity for wood debris, more specifically, Betula, Carpinus, Piceae, and Alnus trees, and produce a farinaceous odor.

Dried Bohemian Psilocybe Mushroom

Their identification dates back to 1969 when Meinhard Moser and Egon Horak brought them to public attention. Their caps mature into a sandy orange-brown color and grow paler when dried. Just like any derivative of P. cubensis, these fungi bruise blue when exposed to oxygen or physical disruption.

Magic Mushrooms: ‘Penis Envy’

With a name like “Penis Envy” we’d expect much introspective complexity to emerge from these mushrooms, and thankfully, this strain does not disappoint. Its bulbous, underdeveloped cap and chunky stem are home to a remarkably high concentration of psilocybin and psilocin. 

Dried Penis Envy Mushroom

These medicinal mushrooms bruise blue and carry a dark-toned appearance, but their stringent need for longer periods of maturation impose strenuous levels of cultivation care, leaving much envy to be felt toward these notoriously hard-to-find mushrooms. 

However, if you can get your hands on this coveted strain, your therapeutic psychedelic experience will undoubtedly mirror the mushroom’s 50% increase in psychoactive concentrations. 

Typical sensations of synesthesia, euphoria, and distorted time, will be present in your journey, but some reports even compare the heightened effects of this strain to the experiences of LSD and DMT, though this is definitely up for debate. So we advise treading lightly in terms of dosage, starting small then working your way up is always the smartest choice.

Magic Mushrooms: B+ Cubensis

B+ Cubensis is a more widely accessible strain of P. cubensis, some believe its genetic origins likely stem from a hybridization with P. azurescens that occurred at least 20 years ago by experienced Floridian cultivator, Mr. G. B+ features a large and lengthy, yellow-white fruiting body and its hallucinogenic effects are known to usher perceptual feelings of warmth and ease. 

Dried B+ Cubensis Mushroom

B+ has gained a reputation for being the ideal beginner strain, since its effects are more moderate and toned-down, as the name implies. Another compliment to the B+ strain is their supernatural ability to reduce side effects of nausea, associated with most other strains of mushrooms. It’s likely that your own supply of mushrooms will be sourced from a larger batch of this strain, as their low-maintenance growth makes them easy and quick to cultivate in bulk.

Magic Mushrooms: Burma, Cambodian, Costa Rican & Ecuadorian Cubensis

These Psilocybe cubensis strains are local to the regions they’re named after. Similar strains include Australia, Chilean, Cuban, and Palenque mushrooms. What bridges these strains together are their akin genetic contents. Though their organic garments vary slightly in shape, size, and potency, this group of mushrooms is relatively reliable at producing a productive psychedelic experience. 

Some, like the Cambodian Cubensis, yields dense flushes with a high level of adaptability to unoptimized growing environments, making them more prevalent amongst mushroom buyers. While others, like the Australian or ‘Aussie’ Cubensis, are fancied for their unique resistance to mold and bacteria.      

Magic Mushrooms ‘Liberty Cap’

‘Liberty Cap’ or ‘Blue legs’ are a common name for the therapeutic psilocybin strain semilanceata. This slimy, cone-capped fungus presents itself as the fourth most potent source of psilocybin and baeocystin—an alkaloid analog of psilocybin (14 mg potency/ 1 dried gram). 

Dried Liberty Cap Mushroom

Being at high demand in the therapeutic psychedelic mushroom market, the Liberty Cap features a signature array of thin strips that run vertically across its cap, with cream-colored gills that turn a purplish-black after maturation and having a particular fondness for moist, grassland habitats. 

Prominent throughout the UK and parts of North America, these glossy capsules of human transcendence are credited for their rich and long standing history. 

Fruiting Liberty Cap Mushroom

In fact, Albert Hofmann, the Swiss chemist who famously synthesized LSD, was also the first to identify this medicinal mushroom’s psychoactive properties in the early 60s. 

Even before that, our psychedelic healing timeline traces the use of Psilocybe semilanceata all the way back to 1799, when its hallucinogenic properties hosted the first known psychedelic mushroom trip, following our primitive ancestors, of course. These small, but resilient organisms accumulate 1.7% psilocybin in their gelatinous caps and contain 0.36% of baeocystin. 

These high levels of psychoactivity surpass those of P. cubensis by a landslide, with the psilocybin content in P. cubensis coming in at a much lower 0.37-1.30% and only 0.14-0.42% psilocin content. So if you’re looking to embark on a potent psychedelic experience, Liberty Caps are surely the way to go.

Magic Mushrooms: Wavy Caps

Though we briefly mentioned these mighty therapeutic mushrooms under the category of fungi that thrive on the surface of decaying wood, Psilocybe cyanescens or ‘Wavy Caps’ nonetheless, deserve a spotlight of their own. As its name suggests, these mushrooms boast a large and flared, umbrella-like cap with rippled ridges, typically measuring 1.5-5 cm across. 

Dried Wavy Cap Mushroom

Another primary definer is their copper-brown color that tends to fade into a paler yellow when they’re put to dry. Their gills produce a similar blue-ish tint when disturbed and contain up to 1.96% psilocybin, certainly putting these medicinal mushrooms at the top of our lists in terms of potency. 

Fruiting Wavy Cap Mushroom

If you’re still concerned with the potential of experiencing wood-lover’s paralysis, you’d be happy to hear that Wavy Caps are often distributed by indoor cultivators who use wood chips as substrate, eliminating the potential for experiencing any somatic motor complications. 

That’s to say, if you have a reliable source of mushrooms who can confirm its cultivation origins, picking up a batch of Psilocybe cyanescens could be a viable option.

Magic Mushrooms: ‘Blue Meanies’

Panaeolus Copelandia Cyanescens or ‘Blue Meanies’, cannot be disregarded. The dramatic potency of this medicinal mushroom strain produces powerful visual and auditory stimulations that melody throughout your entire journey. 

Dried Blue Meanies Mushroom

These bare-striped mushrooms nourish their human counterparts with an energetic vigor of wide-reaching awareness and are no stranger to the psychedelic antics of our modern society. 

Native to neotropical areas like Africa and the Caribbean, these blue-staining fungi offer an average of 2.5% psilocybin and 1.2% psilocin, making them upwards of 3 times more potent than psilocybe cubensis.

The Best Spore Vendor & At-Home Mushroom Grow Kits

Choosing the right method for cultivating mushrooms at home can be a daunting task, given the plethora of options available. To simplify your decision-making process, we’ve narrowed down our focus to two companies: North Spore and Midwest Grow Kits. In addition, Inoculate The World takes first place as our top recommendation for premium mushroom spores.

Our selection is based on their reputation for offering straightforward, cost-effective, and efficient mushroom cultivation solutions. It’s crucial to note that our recommendation is not influenced by affiliate partnerships; rather, these companies have become affiliates due to their commitment to providing valuable and reliable information to our readers.

Explore Harm Reduction Products:

North Spore (10% Off With ‘PSYCHPASSAGE’)

Visit North Spore

Founded in 2014 by a mycologist, an organic farmer and a photojournalist, North Spore is dedicated to making mushroom cultivation accessible to all. They offer a diverse range of products, including premium sawdust, plug, and grain spawn, mushroom grow kits, fruiting blocks, sterile substrates, and medicinal mushroom supplements.

North Spore places a strong emphasis on customer service, ensuring swift order processing, multiple contact options, and a hassle-free return policy.

Boomr Bin Monotub Grow Kit – $150

North Spore Mushroom Grow Kit

Shop ‘Boomr Bin’ Monotub Grow Kit

Their ‘Boomr Bin’ Monotub Grow Kit, priced at $150, is a standout choice for manure-loving mushrooms, reusable housing, improved humidity control, and enhanced airflow.

Midwest Grow Kits (5% Off With ‘PPVIP5’)

Visit Midwest Grow Kits

In partnership with Midwest Organics, Midwest Grow Kits has been a leading supplier of bulk mushroom substrate and automated cultivation kits for over 18 years. Established in 2011, they aim to make mushroom cultivation accessible to hobbyists.

Midwest Grow Kits prioritizes customer satisfaction with fast shipping, diverse contact options, and reasonable return and refund policies.

All-In-One Mushroom Grow Bag – $19.99

Midwest Grow Kit All In One Mushroom Grow Bag

Shop All-In-One Grow Bag

Their ‘All-In-One Mushroom Grow Bag,’ priced at $19.99, is perfect for compact setups, offering a “set it and forget it” approach with easy disposal after harvest.

Mega Mushroom Growing & Incubator Kit – $124.99

Psilocybin Mushroom Grow Kit

Shop Mega Mushroom Growing & Incubator Kit

For serious growers seeking precision, Midwest Grow Kits offers the ‘Mega Mushroom Growing & Incubator Kit’ at $124.99. This advanced kit provides precise control over variables like lighting, heating, and humidity, making it ideal for high-volume production.

Inoculate The World – Your Trusted Spore Source

Visit Inoculate The World

Inoculate The World, established in 2016, is our top recommended medicinal mushroom spore vendor. Known for their legitimacy and excellent support, they offer a wide range of psilocybin mushroom strains.

Psilocybin Mushroom Spores

Shop Premium Mushroom Spores

With a commitment to open-sourcing genetics and timely shipping, they provide reliable spore syringes for both novice and experienced researchers.

Explore the world of mushroom cultivation with confidence, guided by our recommendations for the best grow kits and spore vendors. Whether you’re a beginner or an experienced cultivator, these companies offer solutions tailored to your needs.

Learn More About Psilocybin Mushroom Strains

As we wrap up our journey into the diverse considerations of psilocybin mushroom varieties, remember to explore the various articles in our Psilocybin Mushroom Strain blog series

Each article is crafted to delve into distinct facets of psilocybin mushroom varieties, demystifying this aspect of psychedelic therapy and offering authentic insights instead of simplified responses.

1. Psychedelic Mushroom Strains by Potency: 30 Popular Varieties 

A myth-busting exploration of 30 popular psilocybin mushroom strains, offering pictures, experimental data on their potency, anecdotal reports, and links to purchase each.

2. Can Psilocybin Mushroom Strain Predict Effect Differences?

We examine strain-related effects through anecdotal experiences, Reddit discussions, and scientific perspective. Is a cube(nsis) really just a cube(nsis)?

3. How to Choose a Mushroom Strain for Psychedelic Therapy

A practical guide on selecting a mushroom strain, infused with beginner-friendly Reddit advice, covering therapeutic approaches, dosing intentions, factors like accessibility, consistency, and more.

4. Currently Reading: The Best Mushroom Strain for Psilocybin-Assisted Therapy

We discuss various strains of psilocybin mushrooms for therapeutic use, highlighting their unique properties, cultivation methods, alongside guidance on safe sourcing and therapeutic use. 

Ready To Embark On Your Healing Journey?

Medicinal psilocybin mushrooms and their long list of derivatives are an incredible way to ease into the world of therapeutic psychedelics. Today, we discussed many strains of these psychoactive fungi, but it’s important to note that mushrooms should never be consumed unless you can 100% confirm their identity. 

Referencing books, online guides, and even Reddit subgroups like r/PsilocybinMushrooms, are a great way to get a gauge on the species of your supply, but they’re not the best way. Consulting experienced mycologists or psychedelic facilitators, like one of our own, is the most optimal way to ensure a safe and secure journey. 

Some of the mushrooms listed here have dangerous look-alikes that can pose serious hazards to your health, which is why once again we strongly advise that you source your mushrooms from a reliable cultivator or distributor—or grow your own. 

Traversing this experience alone can be a little confusing sometimes, so we encourage you to book a consultation with one of our knowledgeable psychedelic concierges to identify which psychedelic medicine is best tailored for your needs, and to ensure a safe and seamless integration of your new-found knowledge. 

That’s all for now, friends. If you’re curious about any other psychedelic-related topics, take a peek at our blog page for a large assortment of informational articles that are sure to facilitate your psychedelic journey.


  1. WebMD. (n.d.). Psilocybin: Overview, uses, side effects, precautions, interactions, dosing and reviews. WebMD.
  2.  Johns Hopkins Center for psychedelic and Consciousness Research. Johns Hopkins Medicine. (n.d.).   
  3. Person. (2021, May 26). Psychedelic therapy: Uses, how it’s done, risks, and more. Healthline.  
  4. De Gregorio, D., Aguilar-Valles, A., Preller, K. H., Heifets, B. D., Hibicke, M., Mitchell, J., & Gobbi, G. (2021, February 3). Hallucinogens in mental health: Preclinical and clinical studies on LSD, psilocybin, MDMA, and ketamine. The Journal of neuroscience : the official journal of the Society for Neuroscience.  
  5. Gattuso JJ;Perkins D;Ruffell S;Lawrence AJ;Hoyer D;Jacobson LH;Timmermann C;Castle D;Rossell SL;Downey LA;Pagni BA;Galvão-Coelho NL;Nutt D;Sarris J; (n.d.). Default mode network modulation by psychedelics: A systematic review. The international journal of neuropsychopharmacology.  
  6. Carhart-Harris RL;Bolstridge M;Rucker J;Day CM;Erritzoe D;Kaelen M;Bloomfield M;Rickard JA;Forbes B;Feilding A;Taylor D;Pilling S;Curran VH;Nutt DJ; (n.d.-b). Psilocybin with psychological support for treatment-resistant depression: An open-label Feasibility Study. The lancet. Psychiatry.  
  7. Johnson, M. W., Garcia-Romeu, A., & Griffiths, R. R. (2017, January). Long-term follow-up of psilocybin-facilitated smoking cessation. The American journal of drug and alcohol abuse.   
  8. WebMD. (n.d.). Cancer: Sarcoma, carcinoma, lymphoma, and leukemia. WebMD. 

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